Autoimmune Limbic Encephalitis With GAD Antibodies

GABA(B) receptor antibodies in limbic encephalitis and anti-GAD-associated neurologic disorders.

BACKGROUND γ-Aminobutyric acid-B receptor antibodies (GABA(B)R-ab) were recently described in 15 patients with limbic encephalitis (LE), associated with small-cell lung cancer (SCLC) or with concurrent glutamic acid decarboxylase (GAD) antibodies. We analyzed the frequency of GABA(B)R-ab in 147 patients with LE or neurologic syndromes associated with GAD-ab. METHODS We examined the presence o...

Spontaneously resolving seronegative autoimmune limbic encephalitis.

OBJECTIVE We describe a patient with seronegative autoimmune limbic encephalitis (SNALE) masquerading as glioma. Brain magnetic resonance imaging (MRI) abnormalities, distinctive pathological findings, and spontaneous remission are highlighted. BACKGROUND There are 15 previously reported SNALE cases, 1 with pathology. MATERIALS AND METHODS A 66-year-old man presented with prominent amnestic...

Autoimmune Limbic Encephalitis Associated with Type 1 Diabetes Mellitus

Non-paraneoplastic limbic encephalitis associated with NMDAR and VGKC antibodies.

INTRODUCTION Limbic encephalitis (LE) is characterised by seizures and impairment of short-term memory as well as behavioural and psychiatric symptoms such as anxiety, depression, personality change and hallucinations. Onset of these symptoms is typically subacute over a few weeks or months but may also evolve over a few days. In many patients, limbic encephalitis is a paraneoplastic syndrome u...

Limbic encephalitis with mGluR5 antibodies and immunotherapy-responsive prosopagnosia.